{"id":28982,"date":"2025-11-17T17:42:35","date_gmt":"2025-11-17T09:42:35","guid":{"rendered":"https:\/\/www.rocker.com.tw\/application\/pfas\/"},"modified":"2026-03-09T11:30:53","modified_gmt":"2026-03-09T03:30:53","slug":"pfas","status":"publish","type":"application","link":"https:\/\/www.rocker.com.tw\/en\/application\/pfas\/","title":{"rendered":"PFAS in Water Samples"},"content":{"rendered":"<h1 style=\"text-align: center;\"><strong><span style=\"font-size: 24px;\">PFAS in Water Samples : Analytical Methods and Treatment Strategies<br \/>\n<span style=\"font-size: 20px;\">Key to Sample Handling and Zero-Contamination Workflow<\/span><\/span><\/strong><\/h1>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Per- and polyfluoroalkyl substances (PFAS), widely known as &#8220;forever chemicals&#8221; that have been extensively used since the 1950s, have become a global focus of environmental and health regulation over the past two decades due to their widespread distribution in the environment and potential toxicity. As regulatory requirements demand detection at ultra-trace levels of ng\/L (ppt), accurate detection and quantification (LC-MS\/MS) pose the primary challenge for laboratories aiming to ensure water quality safety.<\/p>\n<p>&nbsp;<\/p>\n<p>This article aims to discuss the regulation and testing of PFAS in water samples, including drinking water, surface water, and wastewater, and to explore how to optimize laboratory procedures and ensure regulatory compliance.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-size: 24px;\"><strong>Table of Contents<\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<div style=\"background-color: #e9eef0; padding: 10px 20px;\">\n<p><a href=\"#A1\"><strong>What are PFAS?<\/strong><\/a><br \/>\n<a href=\"#A2\"><strong>Applications and Sources of PFAS<\/strong><\/a><br \/>\n<a href=\"#A3\"><strong>Health and Carcinogenic Risks of PFAS<\/strong><\/a><br \/>\n<a href=\"#A4\"><strong>Why the World is Starting to Focus on PFAS? The Emerging Environmental Challenge<\/strong><\/a><br \/>\n<a href=\"#A5\"><strong>PFAS Drinking Water Regulations and Standards<\/strong><\/a><br \/>\n<a href=\"#A6\"><strong>PFAS Water Sample Testing Procedures<\/strong><\/a><br \/>\n<a href=\"#A7\"><strong>PFAS Testing Considerations: Contamination Prevention is Paramount<\/strong><\/a><br \/>\n<strong><a href=\"#A8\">Frequently Asked Questions (FAQ)<\/a><\/strong><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-size: 24px;\"><strong><a id=\"A1\"><\/a>What are PFAS?<\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>PFAS (Per- and polyfluoroalkyl substances) are a large class of artificially synthesized fluorinated aliphatic compounds. Due to their high stability, they are widely used in consumer products and industrial fields. PFAS encompass over 10,000 compounds, with common and strictly regulated representative compounds including: Perfluorooctanoic acid (PFOA), Perfluorooctane sulfonic acid (PFOS), Perfluorononanoic acid (PFNA), and Perfluorohexane sulfonic acid (PFHxS).<\/p>\n<p>&nbsp;<\/p>\n<p>PFAS possess extreme thermal and chemical stability, enabling them to resist water, lipids, high temperatures, light, and microbial degradation. Therefore, they have been widely applied in consumer products and industrial sectors since 1950. However, this extreme persistence makes PFAS difficult to decompose in the environment and prone to bioaccumulation in organisms. Hence, PFAS are referred to as &#8220;forever chemicals&#8221; and belong to the group of Persistent Organic Pollutants (POPs) regulated internationally.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><strong><span style=\"font-size: 20px;\"><a id=\"A2\"><\/a><span style=\"font-size: 24px;\">Applications and Sources of PFAS<\/span><\/span><\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>Due to their hydrophobic, oleophobic, and surface-active agent characteristics, PFAS are widely used in various products:<\/p>\n<ul>\n<li>Industrial Uses: Firefighting foams, semiconductor manufacturing processes, specialty chemical materials, etc.<\/li>\n<li>Consumer Products: Stain repellents for carpets, waterproof clothing, food packaging materials, non-stick cookware, cosmetics, paints, etc.<\/li>\n<\/ul>\n<p>These PFAS-containing consumer products, manufacturing facilities, waste (such as landfills), and releases during use are potential sources of PFAS entering and polluting the environment (water, soil, sediment).<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-size: 24px;\"><a id=\"A3\"><\/a><strong>Health and Carcinogenic Risks of PFAS<\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>The persistence of PFAS also leads to their widespread distribution in the environment and their potential entry into the food supply, subsequently appearing in humans and organisms. The primary source of human exposure is food ingestion. Excessive PFAS exposure may lead to a series of health problems and carcinogenic risks, including:<\/p>\n<ul>\n<li><strong>Metabolism and Organs:<\/strong> Elevated cholesterol, increased liver enzymes, thyroid diseases, etc.<strong>.<\/strong><\/li>\n<li><strong>Immune and Reproductive Systems: <\/strong> Immune system suppression, reduced fertility, neurological development issues and reproductive dysfunction in newborns, etc.<strong>.<\/strong><\/li>\n<li><strong>Carcinogenic Risk:<\/strong> The International Agency for Research on Cancer (IARC) has classified PFOA as Group 1 &#8220;Carcinogenic to humans,&#8221; and PFOS as Group 2B &#8220;Possibly carcinogenic to humans.&#8221;<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>To reduce the harm posed by Persistent Organic Pollutants (POPs), the international community signed the Stockholm Convention starting in 2009, progressively listing PFAS and related compounds under regulation, with the aim of controlling and eliminating environmental contamination caused by POPs.<\/p>\n<p>&nbsp;<\/p>\n<p>Related Reading: <a href=\"https:\/\/www.rocker.com.tw\/en\/application\/pfas-testing-in-food-en\/\" target=\"_blank\" rel=\"noopener\">PFAS Testing in Food: Optimizing Sample Preparation with QuEChERS<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><strong><span style=\"font-size: 24px;\"><a id=\"A4\"><\/a>Why the World is Starting to Focus on PFAS? The Emerging Environmental Challenge<\/span><\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>Although these PFAS substances have been widely used for decades, human understanding of the environmental behavior and toxicological effects of these compounds has deepened over the past twenty years.<\/p>\n<p>&nbsp;<\/p>\n<p>Key characteristics exhibited by certain subgroups of PFAS make them a global regulatory focus:<\/p>\n<ul>\n<li><strong>Potential for bioaccumulation:<\/strong> Found in the food chain and subsequently in the blood and tissues of humans and animals.<\/li>\n<li><strong>High mobility in water, soil, and air:<\/strong> Leading to the widespread distribution of PFAS globally.<\/li>\n<li><strong>Long-range transport potential:<\/strong> Traces of PFAS have also been found in remote polar regions.<\/li>\n<li><strong>Eco- and toxicological effects on humans and the environment:<\/strong> Numerous studies have confirmed the impact of PFAS on the environment and health, and monitoring concentrations in many regions already exceed potential risk values.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><strong><span style=\"font-size: 24px;\"><a id=\"A5\"><\/a>PFAS Drinking Water Regulations and Standards<\/span><\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>Regarding PFAS, global regulation is becoming increasingly strict, with various countries setting relevant limits for PFAS in surface water and groundwater. For drinking water, regions such as the United States, the European Union, and Taiwan have either established or are in the process of establishing PFAS standards for drinking water and environmental water quality, as shown in the table below:<\/p>\n<table style=\"border-collapse: collapse;\">\n<tbody>\n<tr>\n<th style=\"width: 33.3333%;\"><strong>Institution<\/strong><\/th>\n<th style=\"width: 33.3333%;\"><strong>Regulation\/Standard<\/strong><\/th>\n<th style=\"width: 33.3333%;\"><strong>Maximum Contaminant Level (MCL) \/ Health Advisory or Guidance Value<\/strong><\/th>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"2\">Taiwan MOENV<\/td>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"2\">Drinking Water Quality Standards<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">PFOA + PFOS \u2264 50 ng\/L<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">PFOS + PFHxS \u2264 70 ng\/L<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"6\">US EPA<\/td>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"6\">National Primary Drinking Water Regulations (NPDWR)<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">PFOA \u2264 4 ppt (ng\/L)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">PFOS \u2264 4 ppt<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">PFHxS \u2264 10 ppt<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">PFNA \u2264 10 ppt<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">HFPO-DA \u2264 10 ppt<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">Mixture of 2 or more*\uff1aHazard Index \u2264 1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; vertical-align: middle; text-align: center;\" rowspan=\"2\">European Environment Agency (EEA)<\/td>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"2\">Drinking Water Directive (DWD)<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">Total PFAS \u2264 0.5 \u00b5g\/L (500 ng\/L)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">Sum of 20 PFAS \u2264 0.1\u00b5g\/L (100 ng\/L)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"2\">World Health Organization (WHO)<\/td>\n<td style=\"width: 33.3333%; text-align: center; vertical-align: middle;\" rowspan=\"2\">WHO draft<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">PFOA \u2264 100 ppt (ng\/L)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">PFOS \u2264 100 ppt<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>* US EPA Mixture Definition: For mixtures containing two or more of PFHxS, PFNA, HFPO-DA, and PFBS, the Hazard Index (HI) must be used.<\/p>\n<p>&nbsp;<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-28031\" src=\"https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/PFAS-Drinking-Water-Standards-Across-Countries.jpg\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/PFAS-Drinking-Water-Standards-Across-Countries.jpg 1280w, https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/PFAS-Drinking-Water-Standards-Across-Countries-768x432.jpg 768w, https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/PFAS-Drinking-Water-Standards-Across-Countries-600x338.jpg 600w\" sizes=\"(max-width: 1280px) 100vw, 1280px\" \/><\/p>\n<p>\u25b2<strong>PFAS Drinking Water Standards Across Countries<\/strong> Image Source: <a href=\"https:\/\/water.moenv.gov.tw\/Public\/CHT\/wsr_1\/WManage\/PFAS.aspx\">Taiwan MOENV Water Quality Protection Web<\/a><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><span style=\"font-size: 24px;\"><strong><a id=\"A6\"><\/a>PFAS Water Sample Testing Procedures<\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>Due to the toxicity risk of PFAS and the need for ultra-low concentration detection (ppt level), testing methods are typically centered around Liquid Chromatography-Tandem Mass Spectrometry (LC-MS\/MS). To achieve low Limits of Quantification (LOQ) and high accuracy, Solid Phase Extraction (SPE) is generally required first to concentrate the sample and remove matrix interference.<\/p>\n<p>&nbsp;<\/p>\n<p>PFAS water sample analysis generally follows international methods such as US EPA Method 1633 or EPA Method 533\/537.1. Taking US EPA Method 1633 \u201dAnalysis of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous, Solid, Biosolids, and Tissue Samples by LC-MS\/MS\u201d as an example, PFAS testing of water samples typically consists of 4 major steps:<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-28054\" src=\"https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/20-\u5b98\u7db2\u61c9\u7528\u5716\u793a-PFAS-En.jpg\" alt=\"\" width=\"1051\" height=\"590\" srcset=\"https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/20-\u5b98\u7db2\u61c9\u7528\u5716\u793a-PFAS-En.jpg 1051w, https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/20-\u5b98\u7db2\u61c9\u7528\u5716\u793a-PFAS-En-768x431.jpg 768w, https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2025\/11\/20-\u5b98\u7db2\u61c9\u7528\u5716\u793a-PFAS-En-600x337.jpg 600w\" sizes=\"(max-width: 1051px) 100vw, 1051px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h3><strong>1. Sample Collection and Preparation<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p>Samples are collected using high-density polyethylene (HDPE) bottles or polypropylene (PP) bottles, and the caps must be linerless. Furthermore, glass sample bottles and pipettes should be avoided to prevent PFAS adsorption onto the glass surface.<\/p>\n<p>US EPA 1633 emphasizes that Extracted Internal Standards (EIS) must be added to the sample prior to sample extraction and clean-up steps.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>2. Extraction and Concentration<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p>When analyte concentrations are too low, <strong>Solid-Phase Extraction (SPE)<\/strong> is used to concentrate the PFAS from a large volume of water sample to achieve low detection limits, such as an enrichment factor of 1:100. Finally, the eluate is concentrated to dryness or near dryness using a nitrogen evaporator (or equivalent solvent evaporation system) and reconstituted with methanol for quantification.<\/p>\n<p>* SPE Cartridge: Waters Oasis WAX 150 mg or equivalent is recommended.<\/p>\n<p>Related Reading: <a href=\"https:\/\/www.rocker.com.tw\/en\/application\/solid_phase_extraction\/\">Solid Phase Extraction (SPE)<\/a><\/p>\n<p>&nbsp;<\/p>\n<h3><strong>3. Clean-up<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p>The sample extract must undergo carbon cleanup to remove interferences. For example, US EPA Method 1633 involves adding Supelclean\u2122 ENVI-Carb\u2122 bulk adsorbent after SPE elution for dispersive clean-up to mitigate the impact of matrix interferences on LC-MS\/MS analysis.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>4. Analysis and Quantification<\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p>Select an appropriate column to ensure efficient separation and resolution, and perform the analysis using Liquid Chromatography coupled with Tandem Mass Spectrometry (LC-MS\/MS). Quantification utilizes the stable-isotope dilution method. Accuracy is ensured by correcting for process losses and matrix effects through the comparison of analytes against the internal standards. The method uses stable-isotope dilution for quantification, specifically comparing analytes against the Extracted Internal Standards (EIS) and Non-Extracted Internal Standards (NIS) to correct for matrix effects and extraction losses, ensuring high accuracy.<\/p>\n<ul>\n<li>Analytical Column: The use of or equivalent is recommended.<br \/>\n* Analytical Column: The use of Waters Acquity UPLC\u00ae BEH C18 column, 1.7 \u00b5m, 50 x 2.1 mm or equivalent is recommended.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2 id=\"h_943446564581763360456892\"><span style=\"font-size: 24px;\"><strong><a id=\"A7\"><\/a>PFAS Testing Considerations: Contamination Prevention is Paramount<\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>The extreme persistence and ubiquitous nature of PFAS mean that laboratories must implement a zero-contamination workflow to avoid cross-contamination or background contamination, which is especially critical in trace analysis.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>1. Containers and Equipment:<\/strong><\/h3>\n<p>\u2022 Containers made of Polypropylene (PP) or High-Density Polyethylene (HDPE) should be used, rinsed with methanol and air-dried before use.<\/p>\n<p>\u2022 Glass containers and pipettes should be avoided to prevent PFAS adsorption onto the glass surface, which can affect results.<\/p>\n<p>\u2022 PP or PE vials should be used for on-instrument analysis.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>2. Solvents and Water Quality:<\/strong><\/h3>\n<p>\u2022 Only <strong>high-purity, PFAS-tested LC-MS-grade solvents<\/strong> must be used.<\/p>\n<p>\u2022 Laboratory water must be ultrapure water (e.g., from a Milli-Q\u00ae water purification system) to ensure no detectable PFAS are present in the water.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>3. Avoid Fluorinated Materials:<\/strong><\/h3>\n<p>\u2022 Consumables and equipment containing fluoropolymers, such as PTFE and FEP, must be strictly avoided during the testing process.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>4. Controlling Instrument System Contamination:<\/strong><\/h3>\n<p>\u2022 Since the LC system&#8217;s pumps and tubing may themselves release PFAS background contamination, it is recommended to install a PFAS delay column when necessary to postpone the background PFAS from the instrument and reduce interference.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_29055\" aria-describedby=\"caption-attachment-29055\" style=\"width: 900px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.rocker.com.tw\/en\/contact\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"wp-image-29055 size-full\" src=\"https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2023\/04\/rocker-scientific-global-dealer-network-quick-quote-1.webp-1.webp\" alt=\"Rocker Global Dealer Network banner offering dedicated support from local experts in USA, India, China, Indonesia, Malaysia, and worldwide for quick quotes.\" width=\"900\" height=\"120\" srcset=\"https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2023\/04\/rocker-scientific-global-dealer-network-quick-quote-1.webp-1.webp 900w, https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2023\/04\/rocker-scientific-global-dealer-network-quick-quote-1.webp-1-768x102.webp 768w, https:\/\/www.rocker.com.tw\/wp-content\/uploads\/2023\/04\/rocker-scientific-global-dealer-network-quick-quote-1.webp-1-600x80.webp 600w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><\/a><figcaption id=\"caption-attachment-29055\" class=\"wp-caption-text\">Global expert support across USA, Asia, and worldwide. \u25b2Click to get a quick quote from your local Rocker dealer.<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<hr \/>\n<h2>\u00a0<\/h2>\n<h2><span style=\"font-size: 20px;\"><strong>Reference Literature<\/strong><\/span><\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"https:\/\/www.epa.gov\/sdwa\/and-polyfluoroalkyl-substances-pfas\">USEPA: Final PFAS National Primary Drinking Water Regulation<\/a><\/li>\n<li><a href=\"https:\/\/www.eea.europa.eu\/en\/analysis\/publications\/pfas-pollution-in-european-waters\">EEA: PFAS pollution in European waters<\/a><\/li>\n<li><a href=\"https:\/\/www.who.int\/teams\/environment-climate-change-and-health\/water-sanitation-and-health\/chemical-hazards-in-drinking-water\/per-and-polyfluoroalkyl-substances\">PFOS and PFOA in Drinking-water: Background document for development of WHO Guidelines for Drinking-water Quality<\/a><\/li>\n<li><a href=\"https:\/\/water.moenv.gov.tw\/Public\/CHT\/wsr_1\/WManage\/PFAS.aspx\">Water Quality Protection Web: PFAS You Need to Know, From Daily Life to Drinking Water<\/a><\/li>\n<li><a href=\"https:\/\/www.epa.gov\/system\/files\/documents\/2024-12\/method-1633a-december-5-2024-508-compliant.pdf\">Method 1633A, Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous, Solid, Biosolids, and Tissue Samples by LC-MS\/MS<\/a><\/li>\n<li><a href=\"https:\/\/www.rootlaw.com.tw\/Attach\/L-Doc\/A040300080003300-1131230-1000-001.pdf\">Method for the Determination of Per- and Polyfluoroalkyl Substances in Water &#8211; Liquid Chromatography Tandem Mass Spectrometry&#8221; (NIEA W542.52B) <\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<h2><strong><span style=\"font-size: 24px;\"><a id=\"A8\"><\/a>Frequently Asked Questions (FAQ)<\/span><\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080;\"><strong>Q1: Are Perfluoroalkyl substances (PFAS) present in the living environment?<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>A1: <\/strong>Investigation reports from multiple countries indicate the presence of PFAS in the environment. PFAS are widely used in waterproof, oil-repellent, and non-stick consumer products, food packaging, and specialty chemical fields. They are released into the living environment\u2014including rivers, seas, sediment, soil, air, dust, and food\u2014through related manufacturing processes, usage, and waste. Therefore, they are widely distributed in the environment.<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080;\"><strong>Q2:<\/strong> <strong>Is PFAS analysis only applicable to drinking water?<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>A2:<\/strong> No. PFAS have been detected in various matrices, including: environmental water samples (groundwater, surface water, wastewater), solid matrices (soil, sludge, biological tissues), food, and beverages (bottled water, seafood, milk, livestock meat, and agricultural products), etc. However, this article only explains the PFAS testing procedure for water samples. Subsequent articles will delve into the detection of PFAS in food.<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080;\"><strong>Q3:<\/strong> <strong>Can PFAS in water be removed by boiling?<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>A3:<\/strong> No, these chemicals cannot be removed by heating or boiling.<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000080;\"><strong>Q4:<\/strong> <strong>Can Pumps and Solid Phase Extraction Devices Cause Sample Contamination?<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>A4:<\/strong> Yes, international and domestic PFAS testing regulations clearly state the risk of contamination: &#8220;Contamination may originate from solvents, reagents, glassware, hardware used in sample processing, and LC system components,&#8221; and explicitly advise <strong>to avoid the use of fluoropolymer materials<\/strong>. To ensure testing accuracy down to the ppt level, contamination must be isolated at the source. Therefore, for Solid Phase Extraction (SPE), a PTFE-free SPE Vacuum Manifold should be used, along with a delay column to purify the background PFAS in the LC system, thereby establishing a reliable zero-contamination workflow.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PFAS in Water Samples : Analytical Methods and Treatment Strategies Key to Sample Handling and Zero-Contamination Workflow &nbsp; &nbsp; Per- and polyfluoroalkyl substances (PFAS), widely known as &#8220;forever chemicals&#8221; that have been extensively used since the 1950s, have become a global focus of environmental and health regulation over the past two decades due to their [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":28045,"parent":0,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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